Regenerative Medicine at Hughes Orthopedics

Treatment for Knee Pain - Contact us Today

Treatment for Knee Pain: PRP or Bone Marrow Concentrate?

To schedule a consultation with Dr. Hughes by calling the San Mateo, California office or by using this number provided: +1-650-343-5633 You can also request an appointment using our booking form online. We will contact you to confirm your appointment as soon as possible.



1 (650) 680-8269



100 S. Ellsworth Ave., #504

San Mateo, CA 94401


*NOTE: Patients cannot enter the waiting room unless they have a scheduled appointment.
We can help you with join pain.

Book an Appointment Today

How did you hear about us? Dr Referral Other

Treatment for Knee Pain

PRP or Bone Marrow Concentrate?

Which to choose before considering a total knee replacement.

By Paul Eliot Hughes, M.D., Founder and CEO of Hughes Orthopedics in San Mateo, CA

Knee pain can be caused by arthritis, degenerative disease, or other conditions including injury for which there are many medical intervention treatments available. It is common for medical doctors to suggest treatment with medications for knee arthritis. Oral medication including Tylenol, non-steroidal anti-inflammatories (NSAIDS) or other oral pain medications (even hydroxycholoquine has been used for severe knee joint inflammation) are commonly used to control the pain but do not change the direction and progression of the disease. When treated by a medical doctor certain medicines can be injected into the painful knee. These injections include corticosteroids or hyaluronic acid (i.e. Synvisc or Hyalgan). But it has been shown that multiple cortisone injections into the knee joints can worsen degeneration and progression of the arthritis. All of these medications are well known and have been effective in many medical practices to treat knee pain for decades. However, these medicines can only treat the symptoms of pain and do not change the underlining pathology of the erosion and degeneration of the cartilage of the knee.

Having accelerated or severe osteoarthritis of the knee is not benign, as advanced arthritis patients were approximately 25 times more likely to have a knee replacement within 9 years than those with mild arthritis. Since the decision to have surgery for an injured knee joint is one that most patients want to avoid, there is a movement in medicine and orthopedic surgery to look for alternative biologic treatments. A new generation of biologic therapies and injections have emerged in recent years to treat knee pain. These treatments are platelet rich plasma and bone marrow concentrate. And both these biologic injection cell therapies not only help relieve people of pain but also can stop the degeneration of the knee joint by restoring, regenerating and repairing the damaged cartilage.

How PRP Works

After conventional treatments for joint pain have failed many patients are now looking into regenerative medicine as a more modern and technologically progressive choice of therapy. PRP is obtained by drawing a small sample of the patient’s own blood (usually just like a normal lab draw) and processing it through a centrifuge that separates the plasma and removes the red blood cells. PRP is an autologous biologic fluid concentrated with activated platelets, which release mediators, growth factors and other cellular agents (cytokines) after being injected into the knee joint. PRP injections reduce inflammation and provide a local healing of the knee cartilage. Thus platelet rich plasma can reduce knee pain and increase activity level of the patient. Platelet rich plasma has been praised by professional athletes like Tiger Woods, who have used regenerative medicine to help recover from an injured knee.

How Regenerative Medicine Works

Bone marrow concentrate are a certain cell that can evolve and change to become different tissues in our bodies. Not all cells are the same and can come from different sources. In the USA, allergenic stem cells from placentas of live births are harvested to provide fetal cells from the umbilical cord and amniotic tissue. Many medical doctors and orthopedic surgeons treating knee pain prefer to use one’s own autologous stem cells to avoid potential infections of the joint and rejections of the graft as has occurred with fetal cell treatments. These adult mesenchymal stem cells can come from a bone marrow aspirate concentrate.  or adipose (fat) tissue concentrate. An aspiration from the bone or fat (liposuction) is done to get marrow or adipose cells which are prepared for injection by a centrifugation process. These stem cells, unlike PRP which has little or no cells in it, can become cartilage and can heal the injured knee joint. Since PRP and autologous stem cells come from the patient themselves, there is no risk of a transmissible infection and a very low risk of allergic reaction and is a very safe procedure when performed by a well-trained experienced orthopedic surgeon.

Band-aid VS a Solution:

The decision whether to use bone marrow concentrate or plasma can be a place of contention. So, the question can be which one to choose. Both of these sterile injections, when done by an expert, are placed with precision into the knee joint using ultrasound guidance. Plasma has been shown in many studies to decreased knee pain caused by arthritis of the knee. The solution itself cannot become cartilage after injection but signals a healing process using the cytokines and growth factors to stimulate the local tissue to heal. Regenerative medicine treatments can decrease the local inflammatory response that causes the pain in the arthritic painful knees. In addition, cells from bone marrow aspirate concentrate (BMC) can heal our joints by differentiating to become cartilage or other local tissue. Cells have the ability to become bone, cartilage, muscle, tendon, fat or even synovial cells. These are live cells and can be present for long periods of time after the injection signaling local cartilage cells to heal, decrease inflammation and grow cartilage themselves. The presence of cells injected into problematic painful joints can help decrease pain from inflammation by cellular modulation and releasing exosomes. There are studies that have shown that bone marrow concentrate (BMC) can decrease joint pain and can increase the volume of meniscus tissue and cartilage tissue in the knee as seen on MRI. Regenerative medicine is a very powerful treatment for knee pain.

Plasma injections costs less than bone marrow concentrate treatments. There can be a progression of treatment options to try plasma treatment first and if it does not work or not enough relief is achieved than patients can move on to stem cell treatments. An advantage to bone marrow concentrate and adult mesenchymal cell therapy injections is that the by-product of the concentration of the bone marrow aspirate is a platelet pore plasma which is similar to plasma and is used in conjunction to bone marrow concentrate at the time of injection to help nourish and stimulate the stem cells to produce a healing effect. The use of bone marrow cells (mesenchymal or adult stem cells) in orthopedic surgeries has been present for many years. These surgeries were microfracture treatments of knee joints by making small holes in the bone allowing bone marrow cells to leak inside the joint to heal the areas of lost cartilage to promote a healing response. Numerous studies have shown that microfracture in knee arthroscopy surgery can heal the cartilage. The ability to concentrate the bone marrow cells from an aspirate, thus increasing the number of adult stem cells present, gives a potentially higher healing effect in the knee joint compared to a microfracture surgical procedure. Because of the strong cellular effect stem cell therapy tends to have higher potential healing effect on the knee joint than plasma injections and should be considered as the first choice of treatment for the arthritic knee. The earlier a biologic treatment is done the more likelihood of avoiding surgeries such as a total knee replacement because the loss of cartilage can be halted and the healing effect can begin. If all medical therapies including bone marrow concentrate and platelet rich plasma have failed for knee pain in the arthritic knee than one can proceed with a knee replacement or arthroscopic surgery knowing they have tried all reasonable non-operative solutions.

Simply put, the combination of the two of has the power to alleviate pain and inflammation, while simultaneously repair the knee – without evasive surgery. One of the drawbacks to only using plasma, is that a patient has to constantly go back for injections, which can start to add up financially and does not solve the underlining issue. If a patient is able to combine platelet rich plasma with bone marrow concentrate, it provides the patient with a quicker road to recovery, as well as saves money on a lifetime of plasma injections. At Hughes Orthopedics we routinely use bone marrow concentrate with plasma booster injections to increase the healing and regeneration of the knee and typically see significant improvements by 6 months post injections.

In conclusion, choosing regenerative medicine can be a great way to decrease pain and to increase the healing potential of the knee joint. The process is done as an in-office procedure and takes about 1-2 hours with little pain and virtually no recovery time, a little soreness is all that is expected. How do we keep this a relatively pain free procedure? We for one have over 20 years of experience in giving joint injections (over 10,000 performed). Also, our skills in providing local anesthetic is second to none. We expect to keep our patients comfortable during all portions of the procedure from the aspiration of the bone marrow to the injection into the joint. Our patients who have gone through the regenerative medicine procedures always say they are surprised how easy and unexpectedly comfortable the process was. Significant pain relief can happen almost immediately and final improvement is expected by 6-12 months.

One of the drawbacks of the current post COVID-19 epidemic, is that people are stuck are in their homes, they decide to go for a jog and hurt, or reactivate their injury, and because all non-emergency appointments have been temporarily suspended, the patient needs to live with that knee pain until the medical world “reopens.” This can lead to a painful few weeks, or months, as well as depression without getting physical exercise.  We offer the best modern holistic autologous treatments available to point our patients towards a course of recovery and a pain-free lifestyle without the need for surgery.

About Hughes Orthopedics and Addressing Pain During A Post Pandemic Crisis:

At Hughes Orthopedics we have a research study that shows with statistical significance that bone marrow concentrate (BMC) injections in patients with knee pain has successfully shown an increase in the activity scores and a decrease in the pain scores of our patients. Over 85% of our patients have this significant improvement. Our plasma and bone marrow concentrate process is in accordance with FDA and is a safe way to obtain treatment for your knee pain. The earlier the intervention with regenerative medicine is done, an alteration of the natural history of joint disease and degenerative progress can be expected. We are excited to continue providing therapies to the knee and other painful joints including treatments of the shoulder, hip, knee, wrist, hand, elbow and ankle which also are showing pain relief with regenerative treatments.

Please contact our office by phone, message or email about setting up a free 15 Minute telemedicine consultation.

Call us today book your appointment:


Hughes P.E.: The Effects of Autologous Stem Cells from Bone Marrow and Adipose Tissue on Patients with Knee Osteoarthritis, World Stem Cell Conference 2020, Barcelona, Spain (Abstract accepted)

Davis J.E., Liu S.H., Lapane K., Harkey M.S., Price L.L., Lu B., et al.
Adults with incident accelerated knee osteoarthritis are more likely to receive a knee replacement: data from the osteoarthritis initiative. Clin Rheumatol, 37 (2018), pp. 1115-1118

Collins J.E., Losina E., Nevitt M.C., Roemer F.W., Guermazi A., Lynch J.A., et al.
Semiquantitative imaging biomarkers of knee osteoarthritis progression: data from the foundation for the national institutes of health osteoarthritis biomarkers consortium Arthritis Rheumatol, 68 (10) (2016), pp. 2422-2431

Lee W., Ruijgrok L., Boxma-de Klerk B., Kok M.R., Kloppenburg M., Gerards A., et al.
Efficacy of hydroxychloroquine in hand osteoarthritis: a randomized, double blind, placebo-controlled trial. Arthritis Care Res (Hoboken), 9 (2017), pp. 1320-1325

Julien Freitag, Dan Bates, James Wickham, Kiran Shah, Leesa Huguenin, Abi Tenen, Kade Paterson, Richard Boyd. Adipose-derived mesenchymal stem cell therapy in the treatment of knee osteoarthritis: a randomized controlled trial. Regenerative medicine 14 (3), 213-230, 2019

Yong Huang, Xiaolu Liu, Xinliang Xu, Junbin Liu. Intra-articular injections of platelet-rich plasma, hyaluronic acid or corticosteroids for knee osteoarthritis. Der Orthopäde 48 (3), 239-247, 2019

Patel S., Dhillon M.S., Aggarwal S., Marwaha N., Jain A.: Treatment with platelet-rich plasma is more effective than placebo for knee osteoarthritis: Prospective, double-blind, randomized trial. Am J sports Med 2013; 356-364

Chahala J., Edan C.S., Moatshe FG., Pascual-Garrido C. Serra Cruz R., LaPrade R.F.: Concentrated bone marrow aspirate for the treatment of chondral injuries and osteoarthritis of the knee: A systematic review of outcomes. Orthop J Sports Med 2016;2325967115625481